Senior/Principal Scientist, Small Molecule Therapeutics

Highlights

• Lead early hit identification to discover novel chemical matter.
• Build AI-enabled small molecule screening platform with automation.
• Drive hits from validation through hit-to-lead workflows.

What they offer

• Competitive base compensation with bonus potential and early-stage equity
• Medical, dental and vision coverage
• Employer-paid life and disability insurance
• Flexible time off with company-wide holidays
• Paid parental leave
• Educational assistance program
• Company-subsidized lunch program

Ideal candidate

Drug discovery scientist with 6+ years in small-molecule hit finding who thrives in fast-paced, automation-driven teams and loves building screening platforms that power AI-guided chemistry.

Requirements

• PhD in biology or related field with 6-8 years drug discovery experience or MS/BS with 10+ years
• Proven success designing and executing DNA-encoded library screening campaigns to validated hits
• Working knowledge of complementary hit-finding modalities including fragment, affinity and functional approaches
• Experience developing and optimizing biochemical and biophysical assays for hit validation
• Hands-on affinity characterization using methods such as SPR, BLI, DSF, ITC or MST
• Experience in automation-enabled labs with liquid handling and scalable workflows
• Ability to partner on protein construct strategy, expression and quality criteria for screening
• Understanding of hit-to-lead funnel including counterscreens, artifact mitigation and data packages
• Track record collaborating across chemistry, biology, automation and computational teams