Associate Scientist, AAV Vector Production
Manifold Bio · Boston Office
Bio & Science AIonsitemid-level$100k–$115k
At a glance
Highlights
- Generate high-quality AAV lots that enable rodent and NHP in vivo studies.
- Power large-scale in vivo screening of novel proteins using molecular barcoding.
- Drive datasets that fuel AI-guided protein design for tissue-targeted medicines.
What they offer
- Annual performance-based target bonus
- Stock options
- Comprehensive medical, dental and vision coverage
- 401(k) plan
- Flexible paid time off and holidays
- Perks including on-site gym, onsite lunch and commuter support
Ideal candidate
Meticulous, organized scientist with a few years in biologics who loves hands-on lab work and clear documentation. You thrive juggling projects in fast, collaborative teams bridging experiments and computation to advance breakthrough treatments.
Requirements
- B.S. or M.S. in biochemistry, molecular biology, chemical engineering, virology or related field with 2-5 years industry experience
- Hands-on AAV production in HEK293 via triple transfection from ≤1 L to ≥50 L scale
- Skilled in downstream purification including affinity and ion-exchange chromatography or ultracentrifugation
- Experienced with qPCR/ddPCR titer assays and capsid quantification via ELISA, western blot and A260/280
- Familiar with purity assays including SEC-HPLC/UHPLC, CGE, LC-MS and SDS-PAGE with troubleshooting ability
Lab profile
About Manifold Bio
Platform biotech using AI-guided protein design and multiplexed in vivo screening for tissue-targeted medicines.
What they build
- Tissue-targeted medicines
- Organism-scale models of living systems
- AI-guided protein design platform
Known for
- Massively multiplexed in vivo screening
- Proprietary molecular barcoding technology
- In vivo-validated datasets at scale
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